| First Author | Parker JC | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 236 |
| Issue | 3 | Pages | 665-9 |
| PubMed ID | 9245710 | Mgi Jnum | J:42064 |
| Mgi Id | MGI:895002 | Doi | 10.1006/bbrc.1997.7034 |
| Citation | Parker JC, et al. (1997) Modulation of insulin secretion and glycemia by selective inhibition of cyclic AMP phosphodiesterase III. Biochem Biophys Res Commun 236(3):665-9 |
| abstractText | The effects of selective inhibition of cyclic AMP phosphodiesterase type III on insulin and glucose levels during an oral glucose challenge were evaluated in obese, diabetic ob/ob mice and in lean, non-diabetic littermates using the selective inhibitor, milrinone. Oral administration of milrinone increased plasma insulin levels both in ob/ob and in lean mice. Glucose tolerance was improved in lean, but not in ob/ob mice, where glucose levels were increased by milrinone treatment. In isolated hepatocytes from normal rats incubation with 200 microM milrinone caused a 30% increase in glucose release with a corresponding depletion of glycogen stores. Stimulation of isolated rat adipocytes with 200 microM milrinone increased glycerol release 7-fold. We conclude that selective inhibitors of cyclic AMP phosphodiesterase III are effective insulin secretagogues, but their therapeutic utility may be limited by their concurrent stimulation of lipolysis and hepatic glucose output. |
