| First Author | Khan A | Year | 1998 |
| Journal | Metabolism | Volume | 47 |
| Issue | 6 | Pages | 627-9 |
| PubMed ID | 9627357 | Mgi Jnum | J:48045 |
| Mgi Id | MGI:1261671 | Doi | 10.1016/s0026-0495(98)90021-x |
| Citation | Khan A, et al. (1998) Glucose-6-phosphatase activity in the hypothalamus of the ob/ob mouse. Metabolism 47(6):627-9 |
| abstractText | The hypothalamus and cortex from ob/ob mice and their lean littermates were sonicated and then incubated with glucose-6-phosphate (glucose-6-P) and glycerol phosphate (glycerol-P). The difference between the rates of hydrolysis of glucose-6-P and glycerol-P was taken as the measure of glucose-6-phosphatase activity. The activity was much higher in the hypothalamus from ob/ob mice versus their lean littermates. Activity was undetected in the cortex. These findings raise the possibility that a defect in the regulation of glucose-6-phosphatase activity in a portion of the hypothalamus may relate to the mechanism underlying obesity in the ob/ob mouse. However, obese gene product administration to ob/ob mice, while reducing the body weight, did not alter the glucose-6-phosphatase activity. |
