| First Author | Zaki PA | Year | 2005 |
| Journal | Eur J Neurosci | Volume | 22 |
| Issue | 6 | Pages | 1547-51 |
| PubMed ID | 16190908 | Mgi Jnum | J:101556 |
| Mgi Id | MGI:3604259 | Doi | 10.1111/j.1460-9568.2005.04323.x |
| Citation | Zaki PA, et al. (2005) Loss of Gli3 enhances the viability of embryonic telencephalic cells in vitro. Eur J Neurosci 22(6):1547-51 |
| abstractText | The transcription factor Gli3 is important for brain and limb development. Mice homozygous for a mutation in Gli3 (Gli3Xt/Xt) have severe abnormalities of telencephalic development and previous studies have suggested that aberrant cell death may contribute to the Gli3Xt/Xt phenotype. We demonstrate that telencephalic cells from embryonic Gli3Xt/Xt embryos survive better and are more resistant to death induced by cytosine arabinoside, a nucleoside analogue that induces death in neuronal progenitors and neurons, than are control counterparts in vitro. Culture medium conditioned by Gli3Xt/Xt cells is more effective at enhancing the viability of control telencephalic cells than medium conditioned by control cells, indicating that Gli3Xt/Xt cells release a factor or factors which enhance telencephalic cell viability. Gli3(Xt/Xt) cells are also more sensitive to released factors present in conditioned media. These data suggest that Gli3 plays both cell-autonomous and cell-nonautonomous roles in mediating telencephalic cell viability. |
