| First Author | Kofler R | Year | 1991 |
| Journal | J Immunol | Volume | 146 |
| Issue | 4 | Pages | 1375-9 |
| PubMed ID | 1991974 | Mgi Jnum | J:10973 |
| Mgi Id | MGI:59415 | Doi | 10.4049/jimmunol.146.4.1375 |
| Citation | Kofler R, et al. (1991) An autosomal recessive gene that delays expression of lupus in BXSB mice. J Immunol 146(4):1375-9 |
| abstractText | We report the generation and serologic, cellular, histologic, and genetic characteristics of a BXSB/MpJScr substrain, termed BXSB/MpJScr-ll/ll, that has lost early-life male lupus disease. Classic genetic analysis suggested that delayed disease expression results from the action of a single autosomal recessive gene. This putative gene, referred to as ll (long-lived), causes a significant delay in expression of autoimmune serology (total serum IgG and anti-nuclear antibodies levels), monocytosis, and of immune complex-mediated histopathologic changes such as glomerulonephritis, arteritis, and myocardial infarction. Presumably as a consequence of the delayed immunopathology male BXSB/MpJScr-ll/ll mice live three to four times longer than regular BXSB/MpJScr. This strain might be useful for analysis of single genes responsible for severe autoimmune disease expression. |
