Primary Identifier | MGI:1856290 | Allele Type | Spontaneous |
Gene | Grem1 | Inheritance Mode | Recessive |
Strain of Origin | CBA/Ca-Bmp5<se> | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A G-to-A transition mutation at the boundary between intron 1 and exon 2 disrupts pre-mRNA splicing by eliminating the AG motif at the 3' splice acceptor site. The aberrant transcript expressed by this allele has a 65 base deletion of the 5' part of exon 2 and is missing the translational start codon. |