| First Author | Wines ME | Year | 2000 |
| Journal | Genomics | Volume | 68 |
| Issue | 3 | Pages | 322-9 |
| PubMed ID | 10995574 | Mgi Jnum | J:61859 |
| Mgi Id | MGI:1855677 | Doi | 10.1006/geno.2000.6264 |
| Citation | Wines ME, et al. (2000) Physical localization of the mesoderm development (mesd) functional region. Genomics 68(3):322-9 |
| abstractText | The mesoderm development (mesd) functional interval is essential for primitive streak formation and mesoderm induction. Mesd is defined by overlapping albino (c) deletions on chromosome 7. We have constructed a bacterial artificial chromosome (BAC) contig that spans the mesd functional region. BAC end-sequence identifies three segments that recognize novel expressed sequences. Localization of the proximal breakpoints from Del(7)Tyr(c-3YPSd) and Del(7)Tyr(c-112K) within the contig defines a deletion interval of 310-350 kb that is essential for mesd function. Importantly, using BAC transgene rescue, we define a 75-kb mesd critical region containing at least one expressed sequence. Copyright 2000 Academic Press. |
