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Publication : A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.

First Author  Moser AR Year  1990
Journal  Science Volume  247
Issue  4940 Pages  322-4
PubMed ID  2296722 Mgi Jnum  J:10209
Mgi Id  MGI:58664 Doi  10.1126/science.2296722
Citation  Moser AR, et al. (1990) A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247(4940):322-4
abstractText  In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.
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