| First Author | Moser AR | Year | 1995 |
| Journal | Eur J Cancer | Volume | 31A |
| Issue | 7-8 | Pages | 1061-4 |
| PubMed ID | 7576992 | Mgi Jnum | J:28572 |
| Mgi Id | MGI:76095 | Doi | 10.1016/0959-8049(95)00181-h |
| Citation | Moser AR, et al. (1995) ApcMin: a mouse model for intestinal and mammary tumorigenesis. Eur J Cancer 31A(7-8):1061-4 |
| abstractText | Min (multiple intestinal neoplasia) is a mutant allele of the murine Apc (adenomatous polyposis coli) locus, encoding a nonsense mutation at codon 850. Like humans with germline mutations in APC, Min/+ mice are predisposed to intestinal adenoma formation. The number of adenomas is influenced by modifier loci carried by different inbred strains. One modifier locus, Mom-1 (modifier of Min-1), maps to distal chromosome 4. Intestinal tumours from both B6 (C57BL/6J) and hybrid Min/+ mice show extensive loss of the wild-type allele at Apc. B6 Min/+ female mice are predisposed to spontaneous mammary tumours. The incidence of both intestinal and mammary tumours can be increased in an age-specific manner by treatment with ethylnitrosourea (ENU). Min mice provide a good animal model for studying the role of Apc and interacting genes in the initiation and progression of intestinal and mammary tumorigenesis. |
