| First Author | Steffensen IL | Year | 2006 |
| Journal | Cancer Lett | Volume | 240 |
| Issue | 2 | Pages | 289-96 |
| PubMed ID | 16343741 | Mgi Jnum | J:114594 |
| Mgi Id | MGI:3689474 | Doi | 10.1016/j.canlet.2005.09.015 |
| Citation | Steffensen IL, et al. (2006) Impact of genetic background on spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis in Min/+ mice. Cancer Lett 240(2):289-96 |
| abstractText | We have studied the impact of genetic background on susceptibility to spontaneous or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced intestinal tumorigenesis. The increase in small intestinal tumor number after PhIP exposure was 3.8- and 3.7-fold above the spontaneous levels in multiple intestinal neoplasia (Min)/+ F1 mice with AKR/J and A/J backgrounds, respectively, compared with only 3-fold in C57BL/6J mice. In the colon, PhIP increased the number of tumors slightly more in C57BL/6J mice (3.3-fold) than in A/J mice (3.0-fold). AKR/J mice had no colonic tumors. Most of the tumors were located in the distal two-thirds of the small intestine in all three strains. |
