| First Author | Das S | Year | 2018 |
| Journal | PLoS One | Volume | 13 |
| Issue | 9 | Pages | e0204181 |
| PubMed ID | 30235302 | Mgi Jnum | J:266734 |
| Mgi Id | MGI:6202218 | Doi | 10.1371/journal.pone.0204181 |
| Citation | Das S, et al. (2018) beta7 integrins contribute to intestinal tumor growth in mice. PLoS One 13(9):e0204181 |
| abstractText | The gut homing receptor integrin alpha4beta7 is essential for the migration of pro-inflammatory T cells into the gut mucosa. Since intestinal neoplasia has been associated with chronic inflammation, we investigated whether interfering with gut-homing affects intestinal tumorigenesis. Using chemically induced and spontaneous intestinal tumor models we showed that lack of beta7 integrin significantly impairs tumor growth without affecting tumor frequencies, with a mild translatable effect on overall survival. This correlates with human data showing lower MAdCAM-1 expression and disease-free survival in colorectal cancer patients. Thus, paradoxically in contrast to extra-intestinal tumors, blocking migration of immune cells into the gut might have a positive therapeutic effect on intestinal neoplasia. |
