| First Author | Ishibashi F | Year | 2018 |
| Journal | Stem Cell Reports | Volume | 10 |
| Issue | 1 | Pages | 27-42 |
| PubMed ID | 29233556 | Mgi Jnum | J:258780 |
| Mgi Id | MGI:6147923 | Doi | 10.1016/j.stemcr.2017.11.006 |
| Citation | Ishibashi F, et al. (2018) Contribution of ATOH1(+) Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. Stem Cell Reports 10(1):27-42 |
| abstractText | ATOH1 is a master transcription factor for the secretory lineage differentiation of intestinal epithelial cells (IECs). However, the comprehensive contribution of ATOH1(+) secretory lineage IECs to the homeostasis, repair, and tumorigenesis of the intestinal epithelium remains uncertain. Through our ATOH1(+) cell-lineage tracing, we show here that a definite number of ATOH1(+) IECs retain stem cell properties and can form ATOH1(+)IEC-derived clonal ribbons (ATOH1(+)ICRs) under completely homeostatic conditions. Interestingly, colonic ATOH1(+) IECs appeared to exhibit their stem cell function more frequently compared with those of the small intestine. Consistently, the formation of ATOH1(+)ICRs was significantly enhanced upon dextran sodium sulfate colitis-induced mucosal damage. In addition, colonic ATOH1(+) IECs acquired tumor stem cell-like properties in the azoxymethane-DSS tumor model. Our results reveal an unexpected contribution of colonic ATOH1(+) IECs to maintaining the stem cell population under both homeostatic and pathologic conditions and further illustrate the high plasticity of the crypt-intrinsic stem cell hierarchy. |
