| First Author | Nishina T | Year | 2021 |
| Journal | Nat Commun | Volume | 12 |
| Issue | 1 | Pages | 2281 |
| PubMed ID | 33863879 | Mgi Jnum | J:306086 |
| Mgi Id | MGI:6713712 | Doi | 10.1038/s41467-021-22450-3 |
| Citation | Nishina T, et al. (2021) Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer. Nat Commun 12(1):2281 |
| abstractText | Interleukin (IL)-11 is a member of the IL-6 family of cytokines and is involved in multiple cellular responses, including tumor development. However, the origin and functions of IL-11-producing (IL-11(+)) cells are not fully understood. To characterize IL-11(+) cells in vivo, we generate Il11 reporter mice. IL-11(+) cells appear in the colon in murine tumor and acute colitis models. Il11ra1 or Il11 deletion attenuates the development of colitis-associated colorectal cancer. IL-11(+) cells express fibroblast markers and genes associated with cell proliferation and tissue repair. IL-11 induces the activation of colonic fibroblasts and epithelial cells through phosphorylation of STAT3. Human cancer database analysis reveals that the expression of genes enriched in IL-11(+) fibroblasts is elevated in human colorectal cancer and correlated with reduced recurrence-free survival. IL-11(+) fibroblasts activate both tumor cells and fibroblasts via secretion of IL-11, thereby constituting a feed-forward loop between tumor cells and fibroblasts in the tumor microenvironment. |
