| Primary Identifier | MGI:1856319 | Allele Type | Spontaneous |
| Attribute String | Null/knockout | Gene | Ar |
| Inheritance Mode | Dominant | Strain of Origin | (STOCK Eda<Ta> x Atp7a<Mo-blo>)F1 |
| Is Recombinase | false | Is Wild Type | false |
| description | ArTfm acts by causing insensitivity to androgens due to a defect in androgen-binding receptor present in cytosol and nucleus. Most responses to androgens are absent or defective in ArTfm/Y males and are not inducible by administration of androgens (J:5221, J:5532). Androgen receptor is found in kidney, submandibular gland (J:5667) and brain (J:5927). ArTfm/Y males have about 20-25 percent of normal testosterone-binding activity in brain (J:6096) and 10-20 percent in kidney. |
| molecularNote | A frameshift mutation resulting from the deletion of a single cytosine residue generated a premature stop codon at residue 412. The nonsense mutation is expected to preclude the translation of both the DNA- and steroid-binding domains. |
