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Publication : X chromosome-linked muscular dystrophy (mdx) in the mouse.

First Author  Bulfield G Year  1984
Journal  Proc Natl Acad Sci U S A Volume  81
Issue  4 Pages  1189-92
PubMed ID  6583703 Mgi Jnum  J:7361
Mgi Id  MGI:55832 Doi  10.1073/pnas.81.4.1189
Citation  Bulfield G, et al. (1984) X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A 81(4):1189-92
abstractText  An X chromosome-linked mouse mutant (gene symbol, mdx) has been found that has elevated plasma levels of muscle creatine kinase and pyruvate kinase and exhibits histological lesions characteristic of muscular dystrophy. The mutants show mild clinical symptoms and are viable and fertile. Linkage analysis with four X chromosome loci indicates that mdx maps in the Hq Bpa region of the mouse X chromosome. This gives a gene order of mdx-Tfm-Pgk-1-Ags, the same as for the equivalent genes on the human X chromosome.
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