| First Author | Quinlan JG | Year | 1997 |
| Journal | Muscle Nerve | Volume | 20 |
| Issue | 8 | Pages | 1016-23 |
| PubMed ID | 9236793 | Mgi Jnum | J:116234 |
| Mgi Id | MGI:3693196 | Doi | 10.1002/(sici)1097-4598(199708)20:8<1016::aid-mus12>3.0.co;2-t |
| Citation | Quinlan JG, et al. (1997) Regeneration-blocked mdx muscle: in vivo model for testing treatments. Muscle Nerve 20(8):1016-23 |
| abstractText | We have refined the mdx mouse as a clinical model for Duchenne dystrophy. Our power estimates, primary measures, regular sacrifice intervals, and quality checks constitute a high-speed, low-cost system for preclinically testing therapies designed to slow muscle destruction in Duchenne dystrophy. Irradiated (18 Gy) and contralateral shielded anterior tibial muscles were studied in 21-day-old mdx and normal mice at the time of irradiation and 4, 8, 12, 16, and 20 weeks thereafter. Regeneration-blocked mdx (irradiated) muscle expressed muscular dystrophy as progressive wasting after a brief (4 week) period of growth. Regeneration-blocked normal muscle showed stunted growth but neither progressive wasting nor microscopic pathological changes. |
