| First Author | Gannoun-Zaki L | Year | 1995 |
| Journal | FEBS Lett | Volume | 375 |
| Issue | 3 | Pages | 268-72 |
| PubMed ID | 7498514 | Mgi Jnum | J:29965 |
| Mgi Id | MGI:77488 | Doi | 10.1016/0014-5793(95)01225-4 |
| Citation | Gannoun-Zaki L, et al. (1995) Down-regulation of mitochondrial mRNAs in the mdx mouse model for Duchenne muscular dystrophy. FEBS Lett 375(3):268-72 |
| abstractText | In our search for genes up- or down-regulated genes in the mdx mouse model for Duchenne muscular dystrophy, we isolated a down-regulated mitochondrial DNA clone. In addition to this clone, all protein-coding mitochondrial genes tested had tissue-specific and age independent down-regulated expression. This implied mechanisms at the RNA level since no change in the mitochondrial DNA contents were detected. Cytochrome c oxidase activity showed the same range of down-regulated expression. These data provide a molecular basis for energetic metabolism modifications in mdx mice. |
