| First Author | Raivich G | Year | 1994 |
| Journal | Eur J Neurosci | Volume | 6 |
| Issue | 10 | Pages | 1615-8 |
| PubMed ID | 7850025 | Mgi Jnum | J:128182 |
| Mgi Id | MGI:3766369 | Doi | 10.1111/j.1460-9568.1994.tb00552.x |
| Citation | Raivich G, et al. (1994) Inhibition of posttraumatic microglial proliferation in a genetic model of macrophage colony-stimulating factor deficiency in the mouse. Eur J Neurosci 6(10):1615-8 |
| abstractText | Activation and proliferation of microglia are common cellular hallmarks in many different pathological processes of the central nervous system. Although a number of colony-stimulating factors enhance microglial proliferation in vitro, little is known about the endogenous mitogens. In the present study we show a strong and selective inhibition of microglial proliferation in the facial nucleus of osteopetrotic (op/op) mice, with a genetic deficiency in biologically active macrophage colony-stimulating factor (MCSF). Posttraumatic activation of adjacent axotomized neurons and reactive astrocytes was not affected, emphasizing the specificity of MCSF as a microglial growth factor. |
