| First Author | Cohen PE | Year | 1997 |
| Journal | Biol Reprod | Volume | 56 |
| Issue | 1 | Pages | 110-8 |
| PubMed ID | 9002639 | Mgi Jnum | J:38039 |
| Mgi Id | MGI:85431 | Doi | 10.1095/biolreprod56.1.110 |
| Citation | Cohen PE, et al. (1997) Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biol Reprod 56(1):110-8 |
| abstractText | Colony stimulating factor-1 (CSF-1) is a hematopoietic growth factor required far the recruitment, proliferation, and differentiation of mononuclear phagocytes. In addition, CSF-1 is expressed in the female reproductive tract coincident with CSF-1 receptor localization on preovulatory oocytes, ovarian and uterine macrophages, decidual cells, and trophoblast. A role for CSF-1 in female reproduction was confirmed by studies on CSF-1- deficient, osteopetrotic (csfm(op)/csfm(op)) mice, which suffer from low pregnancy rates and smaller litter sizes compared to wild-type mice. The present study was designed to determine the exact causes of the preimplantation fertility defects in these mutant mice. Female csfm(op)/csfm(op) mice have extended estrous cycles compared to wild-type females, and s.c. Administration of CSF-1 from birth restores estrous cyclicity. These mice fail to display the characteristic proestrous surge in circulating estradiol-(17)beta. However, concentrations of this hormone are normal during the remainder of the cycle. Furthermore, csfm(op)/csfm(op) females have significantly lower ovulation rates than wild-type mice, but the implantation rates of fertilized oocytes are normal. Serum pregnancy concentrations of progesterone are also normal in csfm(op)/csfm(op)-females, in line with the relatively normal progression of pregnancy in these mice. Thus, the major effect of CSF-1 on female reproductive function is on the frequency and rate of ovulation, indicating a major role for this growth factor in regulating follicular development and ovulation. |
