| First Author | McCary LC | Year | 1997 |
| Journal | J Bone Miner Res | Volume | 12 |
| Issue | 11 | Pages | 1944-51 |
| PubMed ID | 9383699 | Mgi Jnum | J:44543 |
| Mgi Id | MGI:1100427 | Doi | 10.1359/jbmr.1997.12.11.1944 |
| Citation | McCary LC, et al. (1997) Hypophosphatemia and the development of rickets in osteopetrotic (op/op) mice. J Bone Miner Res 12(11):1944-51 |
| abstractText | Our previous work has shown that op/op mice hyperabsorb dietary calcium in the vitamin D-deficient state and shunt that calcium into bone. Under these conditions, the op/op mice are hypocalcemic. The purpose of this study was to examine calcium metabolism and bone mineralization in vitamin D-deficient op/op mice. First, the op/op mice and their normal littermates were placed on a vitamin D-deficient, low phosphorus diet to limit bone mineralization. Under these circumstances, op/op mice survived, even when calcium was also removed from the diet. If the diet contained phosphate, op/op mice died from hypocalcemic tetany when calcium was also removed from the diet. Furthermore, serum calcium levels became similar to wild type in the op/op mice administered the vitamin D-deficient, low phosphorus diet, and op/op mice were able to increase serum calcium in response to 1,25-dihydroxyvitamin D3. The op/op mice developed rickets when their serum phosphorus level was too low to support bone mineralization. The op/op mice became hypophosphatemic on regimens in which normal mice were able to maintain normal serum phosphorus levels. It appears that the op/op mouse simply requires a higher dietary calcium and phosphorus level to prevent rickets and hypocalcemic tetany since the bone is not available as a source of these minerals. However, the ability of the op/op mouse to mineralize bone at low serum calcium and phosphorus levels remains unexplained. |
