| First Author | Hume DA | Year | 1995 |
| Journal | J Interferon Cytokine Res | Volume | 15 |
| Issue | 4 | Pages | 279-84 |
| PubMed ID | 7627801 | Mgi Jnum | J:25708 |
| Mgi Id | MGI:73417 | Doi | 10.1089/jir.1995.15.279 |
| Citation | Hume DA, et al. (1995) Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?. J Interferon Cytokine Res 15(4):279-84 |
| abstractText | The op/op mouse has a mutation in the macrophage colony-stimulating (CSF-1) gene. The phenotype of gross deficiency in the macrophage and osteoclast lineages corrects significantly with age, suggesting that other factors can substitute for CSF-1. This review examines the evidence that the op/op mouse is completely CSF-1 deficient and considers the possibility that alternative splicing within the CSF-1 gene might bypass the mutation, yielding an incompletely penetrant phenotype. |
