| First Author | Bhandoola A | Year | 1994 |
| Journal | Int Rev Immunol | Volume | 11 |
| Issue | 3 | Pages | 231-44 |
| PubMed ID | 7930847 | Mgi Jnum | J:21989 |
| Mgi Id | MGI:69889 | Doi | 10.3109/08830189409061729 |
| Citation | Bhandoola A, et al. (1994) Gld and lpr mice: single gene mutant models for failed self tolerance. Int Rev Immunol 11(3):231-44 |
| abstractText | Mice homozygous for the gld or lpr mutations develop autoimmunity, and a lymphoproliferative disorder involving accumulation of huge numbers of unusual CD4-CD8-TCR alpha beta lo T cells. Here we review our past work with gld mice, and attempt to explain lymphoproliferation in terms of current models of T cell maturation and self-tolerance induction. The availability of molecular probes to the gene products of lpr and gld should shortly lead to a better understanding of the acquisition of self tolerance during T cell maturation and of autoimmunity. |
