| First Author | Yoshizawa Y | Year | 2014 |
| Journal | Mol Immunol | Volume | 57 |
| Issue | 2 | Pages | 216-9 |
| PubMed ID | 24172225 | Mgi Jnum | J:206184 |
| Mgi Id | MGI:5548047 | Doi | 10.1016/j.molimm.2013.10.002 |
| Citation | Yoshizawa Y, et al. (2014) Involvement of Fcalpha/muR (CD351) in autoantibody production. Mol Immunol 57(2):216-9 |
| abstractText | Antibody exerts various immune responses via binding to Fc receptors expressed on immune cells. Although several reports have demonstrated that IgM prevents autoantibody production, the role of IgM Fc receptors is largely unknown. To analyze the involvement of Fcalpha/muR (CD351), an Fc receptor for IgM and IgA expressed on B cells and follicular dendritic cells (FDCs), in IgM-mediated suppression of autoantibody production, we generated mice deficient in Fcalpha/muR on the background of MRL/MpJ-Fas(lpr/lpr) (Fcamr(-/-)Fas(lpr/lpr)) mice. Fcamr(-/-)Fas(lpr/lpr) mice showed significantly lower titers of IgG autoantibodies against double strand (ds) DNA, histone and cardiolipin in the sera than did Fcamr(+/+)Fas(lpr/lpr) mice. Moreover, Fcamr(-/-)Fas(lpr/lpr) mice showed higher survival rate at the ages of 28, 32 and 40 weeks old, compared with Fcamr(+/+)Fas(lpr/lpr) mice. These results suggest that Fcalpha/muR enhances, rather than suppresses, autoantibody production. |
