| First Author | Kimura MY | Year | 2013 |
| Journal | Nat Immunol | Volume | 14 |
| Issue | 2 | Pages | 143-51 |
| PubMed ID | 23242416 | Mgi Jnum | J:192537 |
| Mgi Id | MGI:5465353 | Doi | 10.1038/ni.2494 |
| Citation | Kimura MY, et al. (2013) IL-7 signaling must be intermittent, not continuous, during CD8(+) T cell homeostasis to promote cell survival instead of cell death. Nat Immunol 14(2):143-51 |
| abstractText | The maintenance of naive CD8(+) T cells is necessary for lifelong immunocompetence but for unknown reasons requires signaling via both interleukin 7 (IL-7) and the T cell antigen receptor (TCR). We now report that naive CD8(+) T cells required IL-7 signaling to be intermittent, not continuous, because prolonged IL-7 signaling induced naive CD8(+) T cells to proliferate, produce interferon-gamma (IFN-gamma) and undergo IFN-gamma-triggered cell death. Homeostatic engagement of the TCR interrupted IL-7 signaling and thereby supported the survival and quiescence of CD8(+) T cells. However, CD8(+) T cells with insufficient TCR affinity for self ligands received prolonged IL-7 signaling and died during homeostasis. In this study we identified regulation of the duration of IL-7 signaling by homeostatic engagement of the TCR as the basis for in vivo CD8(+) T cell homeostasis. |
