| First Author | Sharov AA | Year | 2004 |
| Journal | Cancer Res | Volume | 64 |
| Issue | 17 | Pages | 6266-70 |
| PubMed ID | 15342414 | Mgi Jnum | J:92411 |
| Mgi Id | MGI:3052592 | Doi | 10.1158/0008-5472.CAN-04-1367 |
| Citation | Sharov AA, et al. (2004) Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Res 64(17):6266-70 |
| abstractText | Chemotherapeutic agents induce p53-dependent apoptosis in the hair follicle (HF) resulting in hair loss, a common side effect of cancer therapy. Here, we show that Fas as a p53 target plays important role in the HF response to cyclophosphamide. Specifically, we demonstrate that Fas is up-regulated in HF keratinocytes after cyclophosphamide treatment, Fas ligand-neutralizing antibody partially inhibits HF response to cyclophosphamide in wild-type mice, and Fas knockout mice show significant retardation of cyclophosphamide-induced HF involution associated with reduced Fas-associated death domain and caspase-8 expression. These data raise a possibility to explore blockade of Fas signaling as a part of complex local therapy for inhibiting keratinocyte apoptosis and hair loss induced by chemotherapy. |
