| First Author | ElTanbouly MA | Year | 2020 |
| Journal | Science | Volume | 367 |
| Issue | 6475 | PubMed ID | 31949051 |
| Mgi Jnum | J:285188 | Mgi Id | MGI:6385600 |
| Doi | 10.1126/science.aay0524 | Citation | ElTanbouly MA, et al. (2020) VISTA is a checkpoint regulator for naive T cell quiescence and peripheral tolerance. Science 367(6475) |
| abstractText | Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the development of autoimmunity. Unlike all other NCRs that are expressed on activated T lymphocytes, V-type immunoglobulin domain-containing suppressor of T cell activation (VISTA) is expressed on naive T cells. We report an unexpected heterogeneity within the naive T cell compartment in mice, where loss of VISTA disrupted the major quiescent naive T cell subset and enhanced self-reactivity. Agonistic VISTA engagement increased T cell tolerance by promoting antigen-induced peripheral T cell deletion. Although a critical player in naive T cell homeostasis, the ability of VISTA to restrain naive T cell responses was lost under inflammatory conditions. VISTA is therefore a distinctive NCR of naive T cells that is critical for steady-state maintenance of quiescence and peripheral tolerance. |
