| First Author | Denenberg VH | Year | 1992 |
| Journal | Brain Behav Immun | Volume | 6 |
| Issue | 1 | Pages | 40-9 |
| PubMed ID | 1571603 | Mgi Jnum | J:3768 |
| Mgi Id | MGI:52276 | Doi | 10.1016/0889-1591(92)90058-v |
| Citation | Denenberg VH, et al. (1992) A behavior profile of the MRL/Mp lpr/lpr mouse and its association with hydrocephalus. Brain Behav Immun 6(1):40-9 |
| abstractText | Since the NZB and BXSB autoimmune mouse strains have cortical ectopias and associated behavioral changes, mice from the MRL/l (MRL/Mp lpr/lpr) autoimmune strain were given a series of behavioral tests followed by anatomical analyses of their brains and immune assays of plasma. No cortical ectopias were found, but this strain was discovered to have a high incidence of hydrocephalus: 46% had severe dilatation of the lateral and third ventricles, 30% had moderate dilatation, and 24% had minimal or no enlargement of the ventricles (total N = 57). Those mice in the severe hydrocephalus group were poorer in a nonspatial discrimination learning task, had less paw asymmetry, and were less active in a swimming task. No association was found between degree of hydrocephalus and any immune parameter. |
