| First Author | Sundblad A | Year | 1996 |
| Journal | Int Immunol | Volume | 8 |
| Issue | 2 | Pages | 247-54 |
| PubMed ID | 8671610 | Mgi Jnum | J:31438 |
| Mgi Id | MGI:78946 | Doi | 10.1093/intimm/8.2.247 |
| Citation | Sundblad A, et al. (1996) B-lineage cell deficits in bone marrow of lpr/lpr mice. Int Immunol 8(2):247-54 |
| abstractText | Analyses of bone marrow (BM) lymphocytes in C57BL/6 mice homozygous for the lpr mutation (B6.lpr) disclosed low numbers of pre-a and a cells, as compared with age-matched control B6 mice. BM depletion in B6.lpr mice was selective for a-lineage cells, appeared in young adults, and developed markedly with age and disease progression, contrasting with the peripheral lymphocyte hypercellularity. Normalization of pre-a and a cellularity in BM of B6.lpr mice was observed after administration of polyclonal Ig, that also markedly improved the clinical condition. Isolated pre-a (B220(+) IgM(-)) cells from B6 or B6.lpr mice, however, showed essentially the same rates of IL-7-dependent proliferation and differentiation to B (IgM(+)) cells in culture, indicating that the BM B- lineage deficit is not the result of an intrinsic defect in a cell generation. |
