| First Author | Gonzalez-Martin A | Year | 2016 |
| Journal | Nat Immunol | Volume | 17 |
| Issue | 4 | Pages | 433-40 |
| PubMed ID | 26901150 | Mgi Jnum | J:259144 |
| Mgi Id | MGI:6142499 | Doi | 10.1038/ni.3385 |
| Citation | Gonzalez-Martin A, et al. (2016) The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity. Nat Immunol 17(4):433-40 |
| abstractText | Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library and identified miR-148a as a potent regulator of B cell tolerance. Elevated miR-148a expression impaired B cell tolerance by promoting the survival of immature B cells after engagement of the B cell antigen receptor by suppressing the expression of the autoimmune suppressor Gadd45alpha, the tumor suppressor PTEN and the pro-apoptotic protein Bim. Furthermore, increased expression of miR-148a, which occurs frequently in patients with lupus and lupus-prone mice, facilitated the development of lethal autoimmune disease in a mouse model of lupus. Our studies demonstrate a function for miR-148a as a regulator of B cell tolerance and autoimmunity. |
