| First Author | Kägi D | Year | 1994 |
| Journal | Science | Volume | 265 |
| Issue | 5171 | Pages | 528-30 |
| PubMed ID | 7518614 | Mgi Jnum | J:127697 |
| Mgi Id | MGI:3764619 | Doi | 10.1126/science.7518614 |
| Citation | Kagi D, et al. (1994) Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265(5171):528-30 |
| abstractText | Two molecular mechanisms of T cell-mediated cytotoxicity, one perforin-based, the other Fas-based, have been demonstrated. To determine the extent of their contribution to T cell-mediated cytotoxicity, a range of effector cells from normal control or perforin-deficient mice were tested against a panel of target cells with various levels of Fas expression. All cytotoxicity observed was due to either of these mechanisms, and no third mechanism was detected. Thus, the perforin- and Fas-based mechanisms may account for all T cell-mediated cytotoxicity in short-term in vitro assays. |
