| First Author | Yanagi K | Year | 1996 |
| Journal | Cell Immunol | Volume | 168 |
| Issue | 2 | Pages | 243-50 |
| PubMed ID | 8640871 | Mgi Jnum | J:31851 |
| Mgi Id | MGI:79354 | Doi | 10.1006/cimm.1996.0072 |
| Citation | Yanagi K, et al. (1996) In vivo role of IL-10 and IL-12 during development of Sjogren's syndrome in MRL/Lpr mice. Cell Immunol 168(2):243-50 |
| abstractText | Expression of local cytokine genes including interleukin 10 (IL-10) and IL-12 was analyzed in the salivary gland tissues of MRL/lpr mice with Sjogren's syndrome. We demonstrate a significant role of IL-10 and IL-12 in vivo during development of Sjogren's syndrome in MRL/lpr mice. IL-10 mRNA expression was detected before the onset of disease and was upregulated during the course of autoimmune sialadenitis by RT-PCR. A predominant level of expression of IL-12 mRNA was also detected earlier in the proinflammatory stage of autoimmune sialadenitis. Moreover, MHC class II (I-A(k)) mRNA was detected before the onset of inflammatory lesions until older ages in the salivary glands of MRL/lpr mice. These results suggest that endogenous IL-10 and IL-12 may play important roles on immune-mediated destruction of the salivary glands during development of organ-specific autoimmunity in MRL/ lpr mice. (C) 1996 Academic Press, Inc. |
