| First Author | Chaitin MH | Year | 1996 |
| Journal | Brain Res Dev Brain Res | Volume | 94 |
| Issue | 1 | Pages | 92-8 |
| PubMed ID | 8816281 | Mgi Jnum | J:33822 |
| Mgi Id | MGI:81315 | Doi | 10.1016/0165-3806(96)00046-6 |
| Citation | Chaitin MH, et al. (1996) Distribution of CD44 in the retina during development and the rds degeneration. Brain Res Dev Brain Res 94(1):92-8 |
| abstractText | It was previously demonstrated that the 90 kDa cell adhesion molecule CD44 is localized to Muller cell apical microvilli which project into the interphotoreceptor matrix in the adult retina. For the current report, the distribution of CD44 was studied in developing normal BALB/c mouse retinas and in rds mutant mouse retinas of various ages. Using immunoperoxidase techniques, positive label for CD44 was first detected on Muller cell microvilli after 7 days postnatal in BALB/c retinas and the band of label widened as the microvilli elongated and the retina reached maturity. Labeling of the radiating Muller cell bodies within the retina was also observed during development, and this distribution of CD44 is most likely related to retinal cell differentiation and maturation which are taking place at this time. This label was not observed in mature retinas. In the rds mouse retina, a normal labeling pattern for CD44 was observed on Muller cell microvilli at early ages, prior to photoreceptor degeneration. During the time course of the degeneration, microvillar labeling was still seen, however labeling of the radiating Muller cell bodies within the retina increased dramatically. Following degeneration, the Muller cell microvilli appeared to have retracted or collapsed and the inner retinal labeling was not observed. Only a residual label remained at the level of the outer limiting membrane. The increased presence of CD44 within the rds retina during photoreceptor degeneration is likely due to an upregulation of CD44 synthesis by the Muller cells and/or to the transfer of CD44 from retracting microvilli into lower portions of the Muller cells. |
