| First Author | Eisenman LM | Year | 1998 |
| Journal | J Comp Neurol | Volume | 394 |
| Issue | 4 | Pages | 431-44 |
| PubMed ID | 9590553 | Mgi Jnum | J:47382 |
| Mgi Id | MGI:1203365 | Citation | Eisenman LM, et al. (1998) Regionalization defects in the weaver mouse cerebellum. J Comp Neurol 394(4):431-44 |
| abstractText | The mammalian cerebellum consists of parasagittal bands and transverse zones that are laid down early in development. When the adult cerebellum is immunostained for the Purkinje cell-specific antigen zebrin II (i.e., aldolase C), compartmentation is reflected in alternating zebrin II+ (P+) and zebrin II- bands (P-). The zebrin II phenotype is Purkinje cell autonomous; thus, disruptions in the zebrin pattern may reflect early problems in pattern formation. Zebrin II expression has been examined in the weaver (wv) mouse cerebellum. Both zebrin II+ and zebrin II- Purkinje cells are present in the homozygous weaver (wu/wv) mouse, but they are not distributed normally. In the posterior vermis, although the zebrin II+ bands are wider and multilaminate, the standard compartmentation is present. However, a large zebrin II+ cell mass is absent from the central vermis, and analysis of the anterior lobe reveals several missing zebrin II+ bands. The cytoarchitectonic defects in wv mice are not simply related to the Purkinje cell abnormalities. Instead, serial reconstruction reveals two transverse boundaries-one rostrally in lobule VI and the other caudally in lobule IX-that delineate cytoarchitectonic transverse zones important in cerebellar development. The abnormal zebrin expression pattern in wv/vv mice may be secondary to the deletion of a transverse zone. This is the first demonstration that Purkinje cell compartmentation can be altered by mutation; therefore, the wv mutation should prove valuable in understanding cerebellar regionalization. J. Comp. Neurol. 394:431-444, 1998. (C) 1998 Wiley-Liss, Inc. |
