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Publication : Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus.

First Author  Johnson DK Year  1995
Journal  Genetics Volume  141
Issue  4 Pages  1563-71
PubMed ID  8601494 Mgi Jnum  J:29904
Mgi Id  MGI:77429 Doi  10.1093/genetics/141.4.1563
Citation  Johnson DK, et al. (1995) Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus. Genetics 141(4):1563-71
abstractText  Thirty-six radiation- or chemically induced homozygous- lethal mutations at the p locus in mouse chromosome 7 have been analyzed at 17 loci defined by molecular probes to determine the types of lesions, numbers of pre,aion markers deleted or rearranged, regions of overlap of deletion mutations, and genetic distances between loci. A linear deletion map of the [Myod1, Ldh3] - [Snrpn, Znf127] region has been constructed from the molecular analyses of the p-locus deletions. The utility of these deletions as tools for the isolation and characterization of the genes specifying the neurological, reproductive, and developmental phenotypes genetically mapped to this region will grow as more detailed molecular analyses continue.
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