| First Author | Konyukhov BV | Year | 1990 |
| Journal | Mouse Genome | Volume | 87 |
| Pages | 94-5 | Mgi Jnum | J:29474 |
| Mgi Id | MGI:77007 | Citation | Konyukhov BV, et al. (1990) Analysis of the angora-Y gene expression. Mouse Genome 87:94-5 |
| abstractText | Full text of Mouse Genome contribution: Research News: Analysis of the angora-Y gene expression. Dickie (1963) discovered the angora (go) mutant gene in the BALB/cJ strain. She noted that in homozygotes at weaning the guard hairs were more than twice normal length. Recessive mutation similar to angora arose spontaneously in the C57BL/Lac strain at Stolbovaya Farm (Blandova et al., MNL 36, 56-57,1967). It had been shown that this mutant gene was the allelic one with go. Therefore it was named as angora-Y (goY) (Blandova et al., Laboratory animal strains for biomedical researches. Moscow, 1983). We have studied the rate and duration of the growth phase in samples of juvenile (G) and adult (G3) coat hairs in mice homozygous for the goY gene. It has been found that the hair follicle diameters and the hair growth rate in goY/goY mice are similar to the norm. However, in the mutant mice the growth duration of all coat hair types appears to be longer than that in wild-type mice. The growth phase duration of the guard hairs in G1 and G3 generations coat hairs in goY/goY mice is about 7 and 3 days longer than those in +/+ mice, respectively. The duration of the growth phase for the other hair types (zigzags, auchenes, awls) in go Y/goY mice is 3 days longer than that in +/+ mice. It leads to the increase in the lengths of all types of hairs in the mutants: the guard hairs of G1 and G3 coat generations are about 2 and 1.5 times longer than those of normal mice, respectively. The lengths of other hair types of G1 and G3 coat generations in mutant mice are about 50% and 30% greater than in the norm, respectively. Our results are mainly similar with data on the expression of the go gene (Pennycuik and Raphael, Genet. Res. 44, 283-291, 1984). To our surprise we have found striking large hair follicle diameters reported by these authors. It is evidently the mistake that appeared during preparation of the article. We have shown that the growth phase duration of the G1 guard hairs is twice more than that published in this paper. Decreased growth phase duration of the G1 guard hairs in go/go mice is probably due to the introduction of the N gene in this mutant strain by Australian authors. It is thus concluded that the gene goY is repeated mutation of the go gene. (B.V. Konyukhov, A.S. Berdaliev) |
