| First Author | Lutz C | Year | 1994 |
| Journal | Mouse Genome | Volume | 92 |
| Issue | 2 | Pages | 355 |
| Mgi Jnum | J:19229 | Mgi Id | MGI:67419 |
| Citation | Lutz C (1994) Remutation at the ho, hotfoot, locus. Mouse Genome 92(2):355 |
| abstractText | Full text of Mouse Genome contribution: Research News: 5. Remutation at the ho, hotfoot, locus. Another mutation at the ho locus has been identified. The mutation arose in the B10.D2/nSnJ strain at The Jackson Laboratory and is the eighth reported mutant allele at the ho locus. A complementation test between a DBA/2J-ho4J heterozygote and a known heterozygote of the novel mutant yielded 3 affected mice from a total of 21 progeny. The phenotype of B10. D2 /nSnJ-ho8J is similar to other ho alleles as homozygotes show a quick patting motion of the feet identifiable at 4 weeks of age. At 6 to 8 weeks of age spasms which resemble a twitching motion affecting the entire trunk of the mouse are noticeable. The spasms result in a temporary imbalance, and compensatory forelimb and hindlimb splaying, which increases in severity and frequency with age. B10.D2/nSnJ-ho8J males and females are fertile, however breeding is rare. Since the phenotype of B10. D2/nSnJ-ho8J was not significantly distinguishable from DBA/2J-ho4J, only the DNA from homozygote and heterozygote mice were saved. The DNA can be obtained through the DNA resource service at The Jackson Laboratory. (C. Lutz, W. Frankel) |
