| First Author | Wallace ME | Year | 1988 |
| Journal | Mouse News Lett | Volume | 80 |
| Pages | 153 | Mgi Jnum | J:18108 |
| Mgi Id | MGI:66125 | Citation | Wallace ME (1988) A second mutant from the Peru-Wallace stock. Mouse News Lett 80:153 |
| abstractText | Full text of MNL contribution: A second mutant from the Peru-Wallace stock. The mutant Steel-Peru, S1p, referred to above was the first to appear in a specific locus test using Peru mice. These mice were of Peru-Coppock descent developed by selection for a high rate of chromosome abnormality; this selected stock is now named Peru-Wallace (MNL 78,40). A second dominant mutant has occurred in the specific locus test. It resembles Danforth's short- tail, Sd, in that the heterozygote's tail is of variable length, sometimes with kinks, the homozygote is perinatally lethal, and the heterozygote can be selected for greater or lesser expression. However, it varies in penetrance more widely than Sd+. Crossed into a stock selected for long Sd+-tails (always penetrant), the new mutant's tail becomes largely impenetrant in 1-2 generations. Crossed into strain 129, it is fully penetrant after 2-3 crosses; it becomes more inviable with further crosses until only about 1/3 survive in the isogenic stock and tails are all short, i.e. when the heterozygote survives it is fully penetrant. The inviable heterozygotes die perinatally like the homozygotes, and usually, like them, because they have an imperforate anus and/or urethra. Linkage tests using wsh/short-tail crossed to normal mice have shown a significant association with the W locus. The data, including those with the extremes of penetrance and viability, are: Wsh, normal tail, 26; Wsh, short tail, 8; self, normal tail, 17; self, short tail, 16; Total: 67. The contingency X2 is 5.56, p<0.02. To see whether this is a linkage relation, and i f so to locate the new mutant in chromosome 5, crosses with markers Hm and gc are under way. The only other tail mutant on this chromosome is Tht; this shows thickening of the tail, a feature absent from the new mutant. Given the provisional symbol Tsv, for variable short tail, this mutant is on offer to anyone interested. (Wallace). |
