|  Help  |  About  |  Contact Us

Publication : Rods contribute to the light-induced phase shift of the retinal clock in mammals.

First Author  Calligaro H Year  2019
Journal  PLoS Biol Volume  17
Issue  3 Pages  e2006211
PubMed ID  30822304 Mgi Jnum  J:273084
Mgi Id  MGI:6286427 Doi  10.1371/journal.pbio.2006211
Citation  Calligaro H, et al. (2019) Rods contribute to the light-induced phase shift of the retinal clock in mammals. PLoS Biol 17(3):e2006211
abstractText  While rods, cones, and intrinsically photosensitive melanopsin-containing ganglion cells (ipRGCs) all drive light entrainment of the master circadian pacemaker of the suprachiasmatic nucleus, recent studies have proposed that entrainment of the mouse retinal clock is exclusively mediated by a UV-sensitive photopigment, neuropsin (OPN5). Here, we report that the retinal circadian clock can be phase shifted by short duration and relatively low-irradiance monochromatic light in the visible part of the spectrum, up to 520 nm. Phase shifts exhibit a classical photon dose-response curve. Comparing the response of mouse models that specifically lack middle-wavelength (MW) cones, melanopsin, and/or rods, we found that only the absence of rods prevented light-induced phase shifts of the retinal clock, whereas light-induced phase shifts of locomotor activity are normal. In a "rod-only" mouse model, phase shifting response of the retinal clock to light is conserved. At shorter UV wavelengths, our results also reveal additional recruitment of short-wavelength (SW) cones and/or OPN5. These findings suggest a primary role of rod photoreceptors in the light response of the retinal clock in mammals.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

15 Bio Entities

0 Expression