| First Author | Samardzija M | Year | 2006 |
| Journal | FASEB J | Volume | 20 |
| Issue | 13 | Pages | 2411-3 |
| PubMed ID | 16966486 | Mgi Jnum | J:114638 |
| Mgi Id | MGI:3689652 | Doi | 10.1096/fj.06-5895fje |
| Citation | Samardzija M, et al. (2006) Differential role of Jak-STAT signaling in retinal degenerations. FASEB J 20(13):2411-3 |
| abstractText | Retinal degeneration is a major cause of severe visual impairment or blindness. Understanding the underlying molecular mechanisms is a prerequisite to develop therapeutic approaches for human patients. We show in three mouse models that induced and inherited retinal degeneration induces LIF and CLC as members of the interleukin (IL)-6 family of proteins, activates proteins of the Jak-STAT signaling pathway, and up-regulates suppressors of cytokine signaling as a negative feedback loop. Inhibition of Jak2 leads to protection of photoreceptors in a model of induced but not in a model of inherited retinal degeneration. Differential activation of Akt suggests alternative pathways for cell death and/or survival in different models. Proteins induced during photoreceptor degeneration are not mainly expressed in photoreceptors but in cells of other retinal layers. This suggests a model in which photoreceptor injury is signaled to cells of the inner retina, which in turn initiate a response either to support viability or accelerate death of injured cells. |
