| First Author | Via CS | Year | 1996 |
| Journal | J Immunol | Volume | 157 |
| Issue | 12 | Pages | 5387-93 |
| PubMed ID | 8955186 | Mgi Jnum | J:37623 |
| Mgi Id | MGI:85012 | Doi | 10.4049/jimmunol.157.12.5387 |
| Citation | Via CS, et al. (1996) A major role for the Fas pathway in acute graft-versus-host disease. J Immunol 157(12):5387-93 |
| abstractText | Recent studies have suggested a role for the Fas pathway in the wasting syndrome associated with lpr-->wild-type bone marrow transplants. To directly examine whether Fas ligand has a major role in the development of acute graft- vs-host disease (GVHD), Fas ligand-deficient (gld) mice were used as donors and C3H/HeJ x C57BL/6F(1) as recipients in the parent-into-F-1 model of acute GVHD, Transplantation of C3H/gld spleen cells induced significantly less host lymphoid depletion and was associated with less antihost cytotoxic activity in vitro when compared with wild-type C3H donor cells. The reduced depletion of host lymphocytes was explained by both impaired antihost T cell cytolytic activity and by reduced expansion of gld donor T cells in F-1 recipients, These findings not only indicate that the Fas ligand is an important effector molecule in acute GVHD, but also provide in vivo evidence supporting a role for Fas/Fas ligand interactions in T cell expansion and maturation. |
