| First Author | Sweet HO | Year | 1993 |
| Journal | Mouse Genome | Volume | 91 |
| Pages | 312-3 | Mgi Jnum | J:30739 |
| Mgi Id | MGI:78493 | Citation | Sweet HO (1993) Waggler and stargazer are allelic. Mouse Genome 91:312-3 |
| abstractText | Full text of Mouse Genome contribution: Research News: 3. Waggler and stargazer are allelic. Waggler (Mouse Genome 1991; 89:52) and stargazer (Epilepsy Research 1990; 7:129-155) are allelic. The gene symbol for waggler becomes stgwag. A mating between a homozygous wag/wag female and a homozygous stg/stg male produced 7 progeny all of which were affected. A previous test for allelism using a homozygous stg/stg female and a heterozygous, +/wag, male produced 16 progeny ten of which were affected. The phenotype of the compound animal is characterized by the choreiform head movement of the stargazer as well as an instability of gait common to both stargazer and waggler. Two of the stg/wag females were backcrossed to the +/wag male sire. This mating produced 26 normal appearing progeny and 22 neurologically affected progeny. Of the 22 affectedprogeny 7 were scored as having the stargazer phenotype, 12 as having the waggler phenotype and 3 were so severely impaired that a distinct identification could not be made. Different strain backgrounds may subtly influence the mutant phenotype. Both stargazer and waggler arose on different inbred strain backgrounds. This most likely accounts for differences in hearing, swimming ability and electrocortiographic recordings for these two alleles. (H.O. Sweet) |
