| First Author | Amador A | Year | 1984 |
| Journal | Biochem Genet | Volume | 22 |
| Issue | 5-6 | Pages | 395-401 |
| PubMed ID | 6087790 | Mgi Jnum | J:7532 |
| Mgi Id | MGI:56002 | Doi | 10.1007/BF00484511 |
| Citation | Amador A, et al. (1984) Autoregulation of testicular luteinizing hormone receptors in hypogonadal (hpg/hpg) mice. Biochem Genet 22(5-6):395-401 |
| abstractText | The autoregulation of testicular luteinizing hormone (LH) receptors was studied in hypogonadal (hpg/hpg) and normal mice. The basal concentration of LH receptors was more than three-fold higher in hpg/hpg than in normal mice. After injection of hCG, hpg/hpg mice showed a decrease in LH receptor levels which was not observed in normal mice. Plasma testosterone was undetectable in hpg/hpg mice, even after treatment with a single dose of hCG. Plasma prolactin levels were higher in hpg/hpg than in normal mice. The increase in basal LH receptor levels is thought to be due to a compensatory mechanism in which elevated prolactin could play a role. The differences between hpg/hpg and normal mice in the autoregulation of LH receptors observed could be due to the hypersensitivity of the physiologically immature testis in hpg/hpg mice to the action of hCG, to gonadotropin deficiency, particularly during the earlier stages of development, or to a direct effect of the hpg locus on the metabolism of LH receptors. |
