| First Author | Sibilia M | Year | 2000 |
| Journal | Cell | Volume | 102 |
| Issue | 2 | Pages | 211-20 |
| PubMed ID | 10943841 | Mgi Jnum | J:63426 |
| Mgi Id | MGI:1860997 | Doi | 10.1016/s0092-8674(00)00026-x |
| Citation | Sibilia M, et al. (2000) The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell 102(2):211-20 |
| abstractText | The EGF receptor (EGFR) is required for skin development and is implicated in epithelial tumor formation. Transgenic mice expressing a dominant form of Son of Sevenless (SOS-F) in basal keratinocytes develop skin papillomas with 100% penetrance. However, tumor formation is inhibited in a hypomorphic (wa2) and null EGFR background. Similarly, EGFR-deficient fibroblasts are resistant to transformation by SOS-F and rasV12, however, tumorigenicity is restored by expression of the anti-apoptotic bcl-2 gene. The K5-SOS-F papillomas and primary keratinocytesfrom wa2 mice display increased apoptosis, reduced Akt phosphorylation and grafting experiments imply a cell-autonomous requirement for EGFR in keratinocytes. Therefore, EGFR functions as a survival factor in oncogenic transformation and provides a valuable target for therapeutic intervention in a broader range of tumors than anticipated. |
