First Author | Fujimoto Y | Year | 1998 |
Journal | Brain Res | Volume | 811 |
Issue | 1-2 | Pages | 156-60 |
PubMed ID | 9804938 | Mgi Jnum | J:51051 |
Mgi Id | MGI:1314529 | Doi | 10.1016/s0006-8993(98)00910-x |
Citation | Fujimoto Y, et al. (1998) Ambiguus nucleus neurons innervating the abdominal esophagus are malpositioned in the reeler mouse. Brain Res 811(1-2):156-60 |
abstractText | To examine whether the migration of ambiguus nucleus (NA) neurons is affected in the reeler mouse, recombinant replication-deficient adenoviral vector carrying E. coli-galactosidase gene (lacZ) was injected into the abdominal esophagus of the reeler mouse and normal control at two months of age prior to 5 days of sacrifice of the animals. In the normal control, lacZ-positive neurons were found in the compact formation of the NA, whereas, in the reeler, they were scattered from the base of the fourth ventricle to the ventro-lateral margin of the medulla. The present study confirmed that NA neurons are malpositioned in the reeler mouse, suggesting that the migration of NA neurons is guided by the reelin-related protein (Reelin). Copyright 1998 Elsevier Science B.V. |