| First Author | Kopjas NN | Year | 2006 |
| Journal | Epilepsy Res | Volume | 69 |
| Issue | 1 | Pages | 87-91 |
| PubMed ID | 16466907 | Mgi Jnum | J:112768 |
| Mgi Id | MGI:3663539 | Doi | 10.1016/j.eplepsyres.2005.12.001 |
| Citation | Kopjas NN, et al. (2006) Reeler mutant mice exhibit seizures during recovery from isoflurane-induced anesthesia. Epilepsy Res 69(1):87-91 |
| abstractText | Reeler mice are a model of cortical malformation with enhanced seizure susceptibility. Data suggest that the propensity to anesthesia-induced seizures may be enhanced in animal models with developmental anomalies. Consequently, reeler mice were monitored behaviorally before, during and after isoflurane anesthesia. During recovery, 12% of reeler homozygotes had class I/II seizures while the remaining 88% exhibited convulsive seizures entailing opisthotonus and forepaw drumming. Similar behavior was not observed in controls. These data reveal that reeler mice display isoflurane-induced seizures and provide support for the hypothesis that developmental anomalies may predispose the central nervous system to anesthesia-induced seizures. |
