| Primary Identifier | MGI:1856404 | Allele Type | Chemically and radiation induced |
| Gene | a | Inheritance Mode | Recessive |
| Strain of Origin | C3H/HeH | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This mutation comprises a paracentric inversion with deletions of 20 and 18 bp from the proximal and distal breakpoints, respectively. A probe from the agouti locus that differentiates polymorphisms between C3H/HeH and 101/H was used to show that the mutation arose on C3H/HeH. The mutating event affected the regulation of agouti, down regulating the expression of pheomelanin. The distal breakpoint is in the intron between exons 1 and 2 of the Itch gene and is responsible for an immunological defect. |
