| First Author | Sweet HO | Year | 1988 |
| Journal | Mouse News Lett | Volume | 81 |
| Pages | 69 | Mgi Jnum | J:64452 |
| Mgi Id | MGI:1889264 | Citation | Sweet HO, et al. (1988) fld - fatty liver dystrophy. Mouse News Lett 81:69 |
| abstractText | Full text of MNL contribution: Research News: 1. New mutants and linkages. b. Fatty liver dystrophy (fld). A new recessive mutation that arose in BALB/cByJ at F152 in 1981 has been identified as a model of a lipid storage disorder. The mutant phenotype is identifiable at birth. Abdomens of fld/fld animals are swollen. The liver appears enlarged and pale in color. These characteristics disappear by the time the mutant is 28 days of age. Growth of the mutant is retarded throughout its lifespan. Hair growth is retarded beginning at seven days of age. At six weeks of age the coat of the mutant appears unkempt and ruffled. Neurological symptoms, a generalized tremor and unsteady gait, are recognizable at 14 days of age and progress slowly throughout life. The adult fld/fld lacks coordination of the hind limbs. When held up by the tail, the mutant clenches the toes of the rear feet and attempts to clasp the rear legs together. Many homozygotes die between 19-35 days of age. Surviving female homozygotes are fertile, but few fld/fld males have bred. Fld is not sex linked; linkage studies with autosomal markers are in progress. Characterization of the lipid storage disorder is being done in collaboration with J. Gordon and C. Langer, Washington University, School of Medicine. This mutant will be available to other investigators when these collaborative studies are complete. (Sweet, E. Birkenmeier, Davisson) |
