| First Author | Doolittle DP | Year | 1975 |
| Journal | J Hered | Volume | 66 |
| Issue | 6 | Pages | 376-80 |
| PubMed ID | 767403 | Mgi Jnum | J:28104 |
| Mgi Id | MGI:75736 | Doi | 10.1093/oxfordjournals.jhered.a108650 |
| Citation | Doolittle DP, et al. (1975) The Goodale white-spotted mice: a historical report. J Hered 66(6):376-80 |
| abstractText | After tracing the history of Dr. Goodale's selection study of white-spotted mice, it appears that the white spotting selected for was controlled by a complex of genetic factors. Spot occurrence was controlled by a single gene pair, causing small white areas on the forehead. The size of head spot was determined by a few modifier gene loci, among which some nonadditive gene action may have taken place. The B locus appeared to be associated with head-spot size, either through linkage or pleiotropic effects. There may also have been some maternal effects on head-spot size. Selection for increased head-spot size was successful, the heritability of the trait being between 0.1 and 0.2. The increase in spot size was fairly slow; a total score of about 13 units was reached over 16 years of selection. Accumulation of factors favoring increased head-spot size led eventually to the appearance of body spots, and selection began to concentrate on these. Body-spot size was controlled by a larger number of gene pairs; gene action appeared to be more nearly additive, and there appeared to be no maternal effect or association with B locus alleles. Heritability of body-spot size was 0.3 to 0.5. Total score increased from 13 to 56 units over the 11 years of selection. |
