| First Author | Hindin D | Year | 1981 |
| Journal | Experientia | Volume | 37 |
| Issue | 11 | Pages | 1149-50 |
| PubMed ID | 6274680 | Mgi Jnum | J:166048 |
| Mgi Id | MGI:4839619 | Doi | 10.1007/BF01989888 |
| Citation | Hindin D, et al. (1981) The brachymorphic mutation of mice and altered developmental patterns of limb bud 3':5' cyclic adenosine monophosphate. Experientia 37(11):1149-50 |
| abstractText | Concentrations of cyclic AMP (cAMP) were determined in paired fore and hind limbs from day 12-16 of development in murine fetuses homozygous for the brachymorphic (bm) mutation and normal controls. A developmental rise in cAMP occurred 1 day earlier in bm/bm than in +/+ hind limbs and cAMP was higher in day-13 bm/bm than in +/+ fore limbs. Since cAMP is well documented to stimulate chondrogenic differentiation, premature cartilage determination secondary to altered levels of cAMP could play a role in bm/bm short-limbed dwarfism. |
