| First Author | Rogers JH | Year | 1985 |
| Journal | J Immunogenet | Volume | 12 |
| Issue | 3 | Pages | 151-65 |
| PubMed ID | 4093612 | Mgi Jnum | J:8204 |
| Mgi Id | MGI:56673 | Doi | 10.1111/j.1744-313x.1985.tb00842.x |
| Citation | Rogers JH, et al. (1985) The arrangement of H-2 class I genes in mouse t haplotypes. J Immunogenet 12(3):151-65 |
| abstractText | The t haplotypes of mouse chromosome 17 bear a number of interesting mutations and rearrangements, some of which map close to the H-2 complex. Since there are many H-2 class I genes of unknown function, we have investigated their arrangement in t haplotypes using genomic Southern blots. We present a detailed chart of the H-2w30 (tw12) complex, and compare it with the arrangement in other t haplotypes and standard mouse haplotypes. The chart shows duplications, deletions, and reshuffling of conserved and divergent regions. The two major features of the t arrangement--large deletions in the Qa and Tla regions--have analogues in some standard strains, so it is unlikely that these deletions are responsible for t-specific phenotypes. The differences between t and standard mouse strains are similar, in nature and in degree, to those between different standard strains. |
