| Primary Identifier | MGI:1856570 | Allele Type | Spontaneous |
| Gene | t | Inheritance Mode | Recessive |
| Strain of Origin | wild-derived | Is Recombinase | false |
| Is Wild Type | false |
| description | This homozygous lethal allele originated in a mouse caught in the New York suburbs. It suppresses recombination and is a member of the complementation group: tw5 ,tw6 ,tw10 ,tw11 ,tw13 ,tw14 ,tw15 ,tw16 ,tw17 ,tw37 , tw38 ,tw39 ,tw41 ,tw46 ,tw47 ,tw74 ,tw75 ,tw80 ,tw81. T/tw5 phenotype is tail-less.
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| molecularNote | This t haplotype includes a mutation in Vps52, Vps52t-w5 that inserts 2 G nucleotides at the start of exon 2 in a stretch of consecutive G nucleotides (9 in the wild-type C57BL/6 sequence) resulting in a frameshift mutation that generates a premature termination codon. The mutation in Vsp52 is responsible for the embryonic lethal homozygous phenotype in this haplotype. |
